Sunday, September 23, 2012

Buy Acular (Ketorolac Tromethamine) online

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Characteristics of substance Ketorolac

Ketorolac Tromethamine - a racemic mixture of (-) S and (+) R forms. Ketorolac Tromethamine may exist in three crystal forms. All forms are equally soluble in water.

Pharmacology

Mode of action - analgesic, anti-inflammatory, antipyretic, antiplatelet.
Inhibits the activity of cyclooxygenase (COX-1 and COX-2) and inhibits the synthesis of PG. Has a pronounced analgesic activity, associated with the S-form. The maximum analgesic effect occurs within 2-3 hours inhibits platelet aggregation, the effect is reversible. Unlike antiagregatsionnogo effect of aspirin (retained for the life of the platelet), the impact of Acular (Ketorolac Tromethamine) on platelet aggregation stops after 24-48 hours Acular (Ketorolac Tromethamine) no sedative or anxiolytic properties.
There are reports on the effectiveness of Acular (Ketorolac Tromethamine) in migraine attacks. Exhibits anti-inflammatory properties when used in ophthalmology in the form of eye drops.

The use of Acular (Ketorolac Tromethamine)

Pain syndrome of moderate to severe intensity, including in the postoperative period (after abdominal, gynecological, orthopedic, urological and other operations), pain in trauma (sprain, fracture, fractures and sprains), pain in osteoarthritis, osteochondrosis, neuralgia, pain in cancer, toothache, pain after dental procedures, if perikoronite, pulp, back pain and muscle pain.

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Contraindications

Hypersensitivity (including to other NSAIDs), "Aspirin" asthma (a combination of bronchial asthma, recurrent nasal polyposis, and paranasal sinuses and intolerance of acetylsalicylic acid and medicines pirazolonovogo series), bronchospasm, angioedema, erosive and ulcerative lesions of the gastrointestinal tract in acute, peptic ulcer, hypovolemia, dehydration, anticoagulation (including hemophilia), a high risk of bleeding or recurrence (including after operations), impaired hematopoiesis, hemorrhagic stroke (confirmed or suspected), bleeding diathesis , renal and / or hepatic insufficiency (plasma creatinine greater than 50 mg / L), concomitant use with other NSAIDs, labor and delivery, the age of 16. Not applicable for pain before and during surgery due to the risk of bleeding, as well as for the treatment of chronic pain.
Category effects on the fetus by FDA - C.

Side effects of Acular (Ketorolac Tromethamine)

The frequency of side effects increases with increasing dose. In clinical trials revealed the following side effects possibly associated with the use of Acular (Ketorolac Tromethamine):
On the part of the digestive tract: gastralgia (13%), nausea (12%), dyspepsia (12%), diarrhea (7%),> 1% - constipation, bloating, a feeling of fullness, vomiting, stomatitis;
The nervous system and sensory organs: headache (17%), dizziness (7%), somnolence (6%);
In post-marketing studies revealed the following side effects:
From the digestive tract: erosive and ulcerative lesions of the gastrointestinal tract (including perforation and / or bleeding - abdominal pain, cramps, or burning in the epigastric region, melena, vomiting-type "coffee grounds", nausea, heartburn, etc.) , cholestatic jaundice, hepatic dysfunction, hepatitis, hepatomegaly, acute pancreatitis.
The nervous system and sensory organs: seizures, psychosis, aseptic meningitis (fever, severe headache, convulsions, stiff neck and / or back).
Cardio-vascular system and blood (hematopoiesis, hemostasis): hypotension, flushing, thrombocytopenia, leukopenia.
Urogenital system: acute renal failure, back pain with or without hematuria and / or azotemia, hemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia), hyponatremia, hyperkalemia, nephritis, renal edema genesis.
For the skin: Lyell's syndrome, Stevens-Johnson syndrome, exfoliative dermatitis, makulopapulleznaya rash, urticaria.
Allergic reactions: anaphylaxis or anaphylactoid reactions, laryngeal edema, tongue edema, angioedema.
Other: bleeding from the wound, myalgia.

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Overdose

Symptoms: lethargy, drowsiness, nausea, vomiting, abdominal pain, the occurrence of peptic ulcers of the stomach and / or erosive gastritis, renal failure, metabolic acidosis.

Dosage and administration

Inside, in / m, in / in. In children, only by injection. Dose picked individually, taking into account the severity of pain. Single dose is 10-30 mg, the dose frequency - up to 4 times a day (every 6-8 hours). The maximum daily dose for elderly patients - 60 mg. The solution was administered in the / m or / in the treatment of acute and severe pain for up to 5 days in children - 2 days. The tablets are used no more than 5-7 days.
Possible appearance in treatment of sleepiness, dizziness, insomnia or depression necessitates compliance with caution while playing in potentially hazardous activities that require attention and psychomotor speed reactions (driving vehicles).

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